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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2C
All Species:
35.15
Human Site:
T499
Identified Species:
64.44
UniProt:
P25092
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25092
NP_004954.2
1073
123369
T499
D
D
D
K
R
R
D
T
I
Q
R
L
R
Q
C
Chimpanzee
Pan troglodytes
XP_528746
1073
123536
T499
D
D
D
K
R
R
D
T
I
Q
R
L
R
Q
C
Rhesus Macaque
Macaca mulatta
XP_001089601
1073
123492
T499
D
D
D
K
R
R
D
T
I
Q
R
L
R
Q
C
Dog
Lupus familis
XP_543798
1072
122882
T497
D
D
D
K
R
R
D
T
I
Q
R
L
R
Q
C
Cat
Felis silvestris
Mouse
Mus musculus
Q3UWA6
1072
123214
T499
D
D
D
R
R
R
D
T
I
Q
R
V
R
Q
C
Rat
Rattus norvegicus
P23897
1072
123448
T498
D
D
D
R
R
R
D
T
I
Q
R
V
R
Q
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520217
1075
122497
T500
D
D
D
K
R
R
D
T
G
P
R
L
R
Q
G
Chicken
Gallus gallus
XP_416207
1070
123254
T496
D
E
D
K
R
R
D
T
T
Q
R
L
R
Q
G
Frog
Xenopus laevis
NP_001079334
1065
122503
S492
D
D
D
K
R
R
D
S
G
P
R
L
Q
I
R
Zebra Danio
Brachydanio rerio
XP_700803
484
55110
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
S533
I
F
Q
I
C
R
Q
S
I
L
V
V
G
E
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
L557
K
G
A
S
R
R
S
L
Q
S
A
P
S
I
S
Sea Urchin
Strong. purpuratus
P16065
1125
126238
H500
D
M
P
P
C
G
F
H
G
E
L
C
T
N
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.5
87.7
N.A.
81.8
82.4
N.A.
73.5
67.7
62.4
31.4
N.A.
27.9
N.A.
24.8
28.6
Protein Similarity:
100
99.5
98.7
93.5
N.A.
90.1
90.7
N.A.
83.7
80.6
77
37.3
N.A.
45.2
N.A.
45.2
46.3
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
80
60
0
N.A.
13.3
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
86.6
73.3
0
N.A.
33.3
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
16
0
0
0
0
0
0
8
0
0
47
% C
% Asp:
77
62
70
0
0
0
70
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
8
0
0
0
8
0
% E
% Phe:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
8
0
0
24
0
0
0
8
0
16
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
8
0
0
0
0
54
0
0
0
0
16
0
% I
% Lys:
8
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
8
0
8
8
54
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
8
8
0
0
0
0
0
16
0
8
0
0
8
% P
% Gln:
0
0
8
0
0
0
8
0
8
54
0
0
8
62
0
% Q
% Arg:
0
0
0
16
77
85
0
0
0
0
70
0
62
0
8
% R
% Ser:
0
0
0
8
0
0
8
16
0
8
0
0
8
0
8
% S
% Thr:
0
0
0
0
0
0
0
62
8
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
8
24
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _